Hey guys. Since the needle runs down the guts of the main jet, main jet size will affect the overall jetting from bottom, mid and of course top. No harm in trying one size up or down and see how it goes. My 18 250GP is running NEDW 3rd and 185 main 42 pilot, stock head, running great, fuel efficient and clean. For an 18 300 std gas gas Australia recomends NECW 3rd, 42 pilot and 175 main. Goodluck with it.
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