I suspect Mark does not have the time to screw around with this. Find a local service with a good rep to help you out, and when cleaned up do a full backup. Anti virus and malware are only as good as the current database of threats and always one step behind. I've been hacked through all the major security software. If possible isolate your systems that access the web for general use from your core business system, and watch where you go!
If you can swing it, a Mac running a windows virtual machine to support your business apps, and everything else in OSx is a solid solution. I've seen a dentist office that does this. I've had ZERO issues with malware and viruses in OSx since I switched from PCs at home. Before that it was a constant battle fixing the family PCs including a couple complete rebuilds from a root kit attack.
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