My first long ride on my 300 was with stock jetting and had a lot of 80-100kph+ road riding in it. It survived fine with 50:1 synthetic but it was kinda hard to find a sweet spot at a steady speed where it would run clean without surging (the 2T ding, ding, dadda ding, ding accompanied by chain slap) or want more throttle as it was on the edge of coming on the pipe. My cleaner jetting (LTR needle) has largely fixed that, but on any 2T, its not wise to close the throttle for extended periods after WOT or even on real long downhills with no throttle for that matter. A little blip of throttle in those situations will make it live longer and give you a warm/fuzzy feeling that things are getting lubed.
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