You'll find most of us gear our bikes to make 2nd useful, and save 1st for goat trail/walking pace/trials like situations. Through singles I typically only ever run in 2nd and 3rd gears which offers a decent spread over power, and that's on a 250cc with less bottom end.
The 300 will easily pull taller gearing, but you may find 1st a touch tall when you really need it (depends on what/where you ride) or more noticeably, that you can have the bike dip off song a little if shifting early from 2nd - 3rd or 3rd - 4th.
Vibes are very noticeable on the 300, especially compared to a 250F. Many threads on what to check to make sure they're not 'excessive'.
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